ENIGMA Abstracts and Presentations

The following conference abstracts and presentations are based on the collaborative work of the ENIGMA consortium:

Stein, J. L., Medland, S. E., Vasquez, A. A., Hibar, D. P., Senstad, R. E., Winkler, A. M., Toro, R., Appel, K., Bartecek, R., Bergmann, Ø., Bernard, M., Brown, A. A., Cannon, D. M., Chakravarty, M. M., Christoforou, A., Domin, M., Grimm, O., Hollinshead, M., Holmes, A. J., Homuth, G., Hottenga, J. -J., Langan, C., Lopez, L. M., Hansell, N. K., Hwang, K. S., Kim, S., Laje, G., Lee, P. H., Liu, X., Loth, E., Lourdusamy, A., Mattingsdal, M., Mohnke, S., Maniega, S. M., Nho, K., Nugent, A. C., O’Brien, C., Papmeyer, M., Pütz, B., Ramasamy, A., Rasmussen, J., Rijpkema, M., Risacher, S. L., Roddey, J. C., Rose, E. J., Ryten, M., Shen, L., Sprooten, E., Strengman, E., Teumer, A., Trabzuni, D., Turner, J., van Eijk, K., van Erp, T. G. M., van Tol, M. -J., Wittfeld, K., Wolf, C., Woudstra, S., Aleman, A., Alhusaini, S., Almasy, L., Binder, E. B., Brohawn, D. G., Cantor, R. M., Carless, M. A., Corvin, A., Czisch, M., Curran, J. E., Davies, G., de Almeida, M. A. A., Delanty, N., Depondt, C., Duggirala, R., Dyer, T. D., Erk, S., Fagerness, J., Fox, P. T., Freimer, N. B., Gill, M., Göring, H. H. H., Hagler, D. J., Hoehn, D., Holsboer, F., Hoogman, M., Hosten, N., Jahanshad, N., Johnson, M. P., Kasperaviciute, D., Kent, J. W., Kochunov, P., Lancaster, J. L., Lawrie, S. M., Liewald, D. C., Mandl, R., Matarin, M., Mattheisen, M., Meisenzahl, E., Melle, I., Moses, E. K., Mühleisen, T. W., Nauck, M., Nöthen, M. M., Olvera, R. L., Pandolfo, M., Pike, G. B., Puls, R., Reinvang, I., Rentería, M. E., Rietschel, M., Roffman, J. L., Royle, N. A., Rujescu, D., Savitz, J., Schnack, H. G., Schnell, K., Seiferth, N., Smith, C., Steen, V. M., Valdés Hernández, M. C., Van den Heuvel, M., van der Wee, N. J., Van Haren, N. E. M., Veltman, J. A., Völzke, H., Walker, R., Westlye, L. T., Whelan, C. D., Agartz, I., Boomsma, D. I., Cavalleri, G. L., Dale, A. M., Djurovic, S., Drevets, W. C., Hagoort, P., Hall, J., Heinz, A., Jack, C. R., Foroud, T. M., Le Hellard, S., Macciardi, F., Montgomery, G. W., Poline, J. B., Porteous, D. J., Sisodiya, S. M., Starr, J. M., Sussmann, J., Toga, A. W., Veltman, D. J., Walter, H., Weiner, M. W., the Alzheimer’s Disease Neuroimaging Initiative (ADNI), EPIGEN Consortium, IMAGEN Consortium, Saguenay Youth Study Group (SYS), Bis, J. C., Ikram, M. A., Smith, A. V., Gudnason, V., Tzourio, C., Vernooij, M. W., Launer, L. J., DeCarli, C., Seshadri, S., Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) Consortium, Andreassen, O. A., Apostolova, L. G., Bastin, M. E., Blangero, J., Brunner, H. G., Buckner, R. L., Cichon, S., Coppola, G., de Zubicaray, G. I., Deary, I. J., Donohoe, G., de Geus, E. J. C., Espeseth, T., Fernández, G., Glahn, D. C., Grabe, H. J., Hardy, J., Hulshoff Pol, H. E., Jenkinson, M., Kahn, R. S., McDonald, C., McIntosh, A. M., McMahon, F. J., McMahon, K. L., Meyer-Lindenberg, A., Morris, D. W., Müller-Myhsok, B., Nichols, T. E., Ophoff, R. A., Paus, T., Pausova, Z., Penninx, B. W., Potkin, S. G., Sämann, P. G., Saykin, A. J., Schumann, G., Smoller, J. W., Wardlaw, J. M., Weale, M. E., Martin, N. G., Franke, B., Wright, M. J., Thompson, P. M., for the Enhancing Neuro Imaging Genetics through Meta-Analysis (ENIGMA) Consortium. [published online ahead of print April 15, 2012]. Identification of common variants associated with human hippocampal and intracranial volumes. Nature Genetics. doi:10.1038/ng.2250

ENIGMA: Enhancing Neuro Imaging Genetics Through Meta-Analysis
Medland, S.E., for the ENIGMA Consortium. (Full author list)
>Australian GeneMapping Conference

Genome-Wide Association Meta-Analysis of Hippocampal Volume via the ENIGMA Consortium
Stein, J.L., for the ENIGMA Consortium. (Full author list) (Abstract)
>Human Brain Mapping Conference 2011

Other References

The following references are a limited sample of papers on imaging, genetics, or imaging genetics that are meant to give an introduction to this field of research.

Candidate Genes

Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia
Egan, M.F., Goldberg, T.E., Kolachana, B.S., Callicott, J.H., Mazzanti, C.M., Straub, R.E., Goldman, D., Weinberger, D.R.
>Pubmed

The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function
Egan, M.F., Kojima, M., Callicott, J.H., Goldberg, T.E., Kolachana, B.S., Bertolino, A., Zaitsev, E., Gold, B., Goldman, D., Dean, M., Lu, B., Weinberger, D.R.
>Pubmed

GWAS Reviews

Genome-wide association studies for complex traits: consensus, uncertainty and challenges
McCarthy, M.I., Abecasis, G.R., Cardon, L.R., Goldstein, D.B., Little, J., Ioannidis, J.P., Hirschhorn, J.N.
>Pubmed

Genomewide association studies–illuminating biologic pathways
Hirschhorn, J.N.
>Pubmed

Common genetic variation and human traits
Goldstein, D.B.
>Pubmed

Finding the missing heritability of complex diseases
Manolio, T.A., Collins, F.S., Cox, N.J., Goldstein, D.B., Hindorff, L.A., Hunter, D.J., McCarthy, M.I., Ramos, E.M., Cardon, L.R., Chakravarti, A., Cho, J.H., Guttmacher, A.E., Kong, A., Kruglyak, L., Mardis, E., Rotimi, C.N., Slatkin, M., Valle, D., Whittemore, A.S., Boehnke, M., Clark, A.G., Eichler, E.E., Gibson, G., Haines, J.L., Mackay, T.F., McCarroll, S.A., Visscher, P.M.
>Pubmed

Imaging Genetics Reviews

Intermediate phenotypes and genetic mechanisms of psychiatric disorders
Meyer-Lindenberg, A., Weinberger, D.R.
>Pubmed

Imaging genomics
Thompson, P.M., Martin, N.G., Wright, M.J.
>Pubmed

GWAS with Imaging Phenotypes

Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study
Seshadri, S., DeStefano, A.L., Au, R., Massaro, J.M., Beiser, A.S., Kelly-Hayes, M., Kase, C.S., D’Agostino, R.B., Sr., Decarli, C., Atwood, L.D., Wolf, P.A.
>Pubmed

Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer’s disease
Potkin, S.G., Guffanti, G., Lakatos, A., Turner, J.A., Kruggel, F., Fallon, J.H., Saykin, A.J., Orro, A., Lupoli, S., Salvi, E., Weiner, M., Macciardi, F.
>Pubmed

A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype
Potkin, S.G., Turner, J.A., Guffanti, G., Lakatos, A., Fallon, J.H., Nguyen, D.D., Mathalon, D., Ford, J., Lauriello, J., Macciardi, F.
>Pubmed

Gene discovery through imaging genetics: identification of two novel genes associated with schizophrenia
Potkin, S.G., Turner, J.A., Fallon, J.A., Lakatos, A., Keator, D.B., Guffanti, G., Macciardi, F.
>Pubmed

Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer’s disease
Stein, J.L., Hua, X., Morra, J.H., Lee, S., Hibar, D.P., Ho, A.J., Leow, A.D., Toga, A.W., Sul, J.H., Kang, H.M., Eskin, E., Saykin, A.J., Shen, L., Foroud, T., Pankratz, N., Huentelman, M.J., Craig, D.W., Gerber, J.D., Allen, A.N., Corneveaux, J.J., Stephan, D.A., Webster, J., Dechairo, B.M., Potkin, S.G., Jack, C.R., Jr., Weiner, M.W., Thompson, P.M.
>Pubmed

Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort
Shen, L., Kim, S., Risacher, S.L., Nho, K., Swaminathan, S., West, J.D., Foroud, T., Pankratz, N., Moore, J.H., Sloan, C.D., Huentelman, M.J., Craig, D.W., Dechairo, B.M., Potkin, S.G., Jack, C.R., Jr., Weiner, M.W., Saykin, A.J.
>Pubmed

Imaging GWAS Methodology

Voxelwise genome-wide association study (vGWAS)
Stein, J.L., Hua, X., Lee, S., Ho, A.J., Leow, A.D., Toga, A.W., Saykin, A.J., Shen, L., Foroud, T., Pankratz, N., Huentelman, M.J., Craig, D.W., Gerber, J.D., Allen, A.N., Corneveaux, J.J., Dechairo, B.M., Potkin, S.G., Weiner, M.W., Thompson, P.M.
>Pubmed

Discovering genetic associations with high-dimensional neuroimaging phenotypes: A sparse reduced-rank regression approach.
Vounou, M., Nichols, T.E., Montana, G.
>Pubmed

Additional Papers on Imaging Genetics

See papers from the Thompson group: http://www.loni.ucla.edu/~thompson/IG/IG.html.

If you have suggestions of key papers on imaging and GWAS, please email them to steinja@ucla.edu.